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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus Article

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Engineering 2023, Volume 28, Issue 9,   Pages 206-221 doi: 10.1016/j.eng.2023.03.006

Abstract: (ADAM10) is exploited to accelerate S. aureus infection through diverse mechanisms.The extraordinary contribution of ADAM10 to S. aureus pathogenesis renders it an attractiveOur study is the first to demonstrate the indispensable role of ADAM10 in S. aureus-inducednecroptosis, and it enhances our knowledge of the role of ADAM10 in S. aureus infection.Using a fluorogenic substrate assay, we further identified kaempferol as a potent ADAM10 inhibitor that

Keywords： Host-directed therapy     Kaempferol     ADAM10 inhibitor     Staphylococcus aureus infection     Barrier disruption    

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Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 195-199 doi: 10.1007/s11684-008-0037-7

Abstract: counting the number of spermatozoa that migrated into the capillary after incubation with uPA for 5, 10, 20, and 30 min, respectively, compared with that after incubation with F10.Meanwhile, to confirm the specific effect of uPA on mouse sperm chemotaxis, uPA inhibitor (PAI-1) andrabbit IgG may affect sperm accumulation nonspecifically, PAI-1 and anti-uPAR rabbit IgG were added to F10

Keywords： chemotactic activity     receptor     uPA inhibitor     F10     chemoattractant    

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3D finite element method (FEM) simulation of groundwater flow during backward erosion piping

Kristine VANDENBOER,Vera van BEEK,Adam BEZUIJEN

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 2,   Pages 160-166 doi: 10.1007/s11709-014-0257-7

Abstract: Backward erosion piping is an important failure mechanism for cohesive water retaining structures which are founded on a sandy aquifer. At present, the prediction models for safety assessment are often based on 2D assumptions. In this work, a 3D numerical approach of the groundwater flow leading to the erosion mechanism of backward erosion piping is presented and discussed. Comparison of the 2D and 3D numerical results explicitly demonstrates the inherent 3D nature of the piping phenomenon. In addition, the influence of the seepage length is investigated and discussed for both piping initiation and piping progression. The results clearly indicate the superiority of the presented 3D numerical model compared to the established 2D approach. Moreover, the 3D numerical results enable a better understanding of the complex physical mechanism involved in backward erosion piping and thus can lead to a significant improvement in the safety assessment of water retaining structures.

Keywords： backward erosion piping     groundwater flow     3D finite element method (FEM)    

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PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0966-y

Abstract: The PM in the submicron mode for burning with raw coal contributes to 33%±10 % of PM emissions, much

Keywords： coal-fired chain-grate boiler     PM10     size distribution     particulate emission control devices    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chainBased on the common axoneme structure of motile cilia and sperm flagella, DNAH10 variants areUsing exome sequencing, we identified a novel DNAH10 homozygous variant (c.589C > T, p.R197W)Immunostaining analysis showed the absence of DNAH10 and DNALI1 in the respiratory ciliaSubsequently, animal models of Dnah10-knockin mice harboring missense variants and Dnah10

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitspublic databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCIn 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patientsMoreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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A simple, azulene-based colorimetric probe for the detection of nitrite in water

López-Alled, Adam C. Sedgwick, Jannis Wenk, Tony D. James, Simon E. Lewis

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 90-96 doi: 10.1007/s11705-019-1790-7

Abstract: We describe the synthesis and evaluation of an azulene-based chemodosimeter for nitrite. The probe was found to undergo two distinct color changes upon introduction aqueous nitrite ion. A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite, followed by the formation of a deep-yellow/orange color, the endpoint from which quantitative data can be derived. The azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water, and is selective for nitrite over other anions. The azulene probe was applied to determine nitrite content in cured meat, and compared with the British Standard testing procedure (Griess test). The value obtained from the azulene-based probe agreed closely with the standard test. Our procedure only requires the preparation of one standard solution, instead of the three required for the standard Griess test.

Keywords： azulene     nitrite     diazoquinone    

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Home location inference from sparse and noisy data: models and applications

Tian-ran HU,Jie-bo LUO,Henry KAUTZ,Adam SADILEK

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 5,   Pages 389-402 doi: 10.1631/FITEE.1500385

Abstract: Accurate home location is increasingly important for urban computing. Existing methods either rely on continuous (and expensive) Global Positioning System (GPS) data or suffer from poor accuracy. In particular, the sparse and noisy nature of social media data poses serious challenges in pinpointing where people live at scale. We revisit this research topic and infer home location within 100 m×100 m squares at 70% accuracy for 76% and 71% of active users in New York City and the Bay Area, respectively. To the best of our knowledge, this is the first time home location has been detected at such a fine granularity using sparse and noisy data. Since people spend a large portion of their time at home, our model enables novel applications. As an example, we focus on modeling people’s health at scale by linking their home locations with publicly available statistics, such as education disparity. Results in multiple geographic regions demonstrate both the effectiveness and added value of our home localization method and reveal insights that eluded earlier studies. In addition, we are able to discover the real buzz in the communities where people live.

Keywords： Home location     Mobility patterns     Healthcare    

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The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Frontiers in Energy 2023, Volume 17, Issue 1,   Pages 1-4 doi: 10.1007/s11708-023-0869-5

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: In this study the effects of lipopolysaccharide (LPS) and interleukin-10 (IL-10) on the formation ofThe cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.However, the significant elevation by LPS was abrogated when IL-10 was added.IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.The inhibitive effect of IL-10 is an important factor for delaying atherosclerosis processes.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

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Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2,   Pages 109-109 doi: 10.1007/s11705-009-0258-6

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Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 102-110 doi: 10.1007/s11684-021-0850-9

Abstract: January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitorAssociations between the use of RAS-I (angiotensin-converting enzyme inhibitor (ACEI) or angiotensin

Keywords： COVID-19     RAS inhibitor     hypertension     all-cause mortality    

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Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 969-974 doi: 10.1007/s11684-021-0912-z

Abstract: A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and Decemberto determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10

Keywords： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

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Comparison between inhibitor and uncoupler for minimizing excess sludge production of an activated sludge

CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 63-66 doi: 10.1007/s11783-007-0012-6

Abstract: minimization of excess sludge production, the reduction in the excess sludge production in the presence of an inhibitor

Keywords： uncoupling coefficient     Cu     minimization     presence     uncoupling    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Title Author Date Type Operation

Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureus

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Journal Article

Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Journal Article

3D finite element method (FEM) simulation of groundwater flow during backward erosion piping

Kristine VANDENBOER,Vera van BEEK,Adam BEZUIJEN

Journal Article

PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

A simple, azulene-based colorimetric probe for the detection of nitrite in water

López-Alled, Adam C. Sedgwick, Jannis Wenk, Tony D. James, Simon E. Lewis

Journal Article

Home location inference from sparse and noisy data: models and applications

Tian-ran HU,Jie-bo LUO,Henry KAUTZ,Adam SADILEK

Journal Article

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Journal Article

Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID

Journal Article

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Journal Article

Comparison between inhibitor and uncoupler for minimizing excess sludge production of an activated sludge

CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article